Fig. 1 | Scientific Reports

Fig. 1

From: A high-density multi-electrode platform examining the effects of radiation on in vitro cortical networks

Fig. 1

Neuronal activity in populations of prefrontal cortical neurons. (A) Left, example of PFC slice placement on the hd-MEA. Right, multiunit spike (identified by an asterisk “*”) extracted from voltage deflections identified at an individual channel. (B) Mean firing rate of prefrontal cortical neurons across various conditions. C = control slices for the radiation treatment; BL = baseline in the PE condition; 20–100 Gy = radiation conditions; EP = epileptiform activity. *indicates statistical significance at p < 0.01. (C) Rasters of activity show spikes across whole populations of neurons following graded doses of radiation or perfusion of pro-epileptiform solution. Peri-stimulus time histogram underneath each raster shows summated activity using a 500 ms rolling window.

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