Table 1 List of significantly different sperm proteins between proteasomally-inhibited IVC spermatozoa compared to IVC vehicle groups.
Gene name | UniProtKB Entry | Protein name | Mass | Up/down regulated* | Biological function in spermatozoa | Localization in spermatozoa | References |
|---|---|---|---|---|---|---|---|
ACAD10 | F1RL48 | Acyl-CoA dehydrogenase family member 10 | 115,840 | Up | Fatty acid metabolism | Midpiece, mitochondria | |
ALB | A0A287AMK0 | Albumin | 69,670 | Up | Component of high-molecular-weight ZP-binding complexes | Acrosomal matrix | |
BTBD16 | I3LJE4 | BTB/POZ domain-containing protein 16 | 58,470 | Up | Unknown | Unknown | |
CFAP161 | F1RID8 | Cilia and flagella associated protein 161 | 35,335 | Up | Unknown | Flagellum | |
CLYBL | A0A5G2R6V1 | Citramalyl-CoA lyase | 35,518 | Up | Unknown | Midpiece, mitochondria | |
CST3 | Q0Z8R0 | Cystatin C | 15,734 | Up | Cysteine Protease Inhibitor/decapacitating factor | Post-acrosomal region, flagellum | |
EEF1A1 | A0A288CG57 | Elongation factor 1-alpha | 49,071 | Down | Unknown | Flagellum | |
FAM205C | A0A5G2QEV9 | Family with sequence similarity 205 member C | 152,820 | Up | Unknown | Unknown | |
H2AC1 | A0A5G2RMV0 | Histone H2A | 14,246 | Up | DNA packaging, epigenetic memory | Nucleus, perinuclear theca | |
KLK8 | A0A286ZM99 | Kallikrein related peptidase 8 | 28,217 | Down | Unknown | Unknown | |
MT-ND2 | O79875 | NADH-ubiquinone oxidoreductase chain 2 | 39,056 | Down | Oxidative phosphorylation | Midpiece, mitochondria | |
RAB2A | F1RT87 | RAB2A, member RAS onco family | 25,152 | Up | Acrosome biogenesis, zona binding | Perinuclear theca, periacrosomal plasma membrane | |
TTR | A0A5G2QIE9 | Transthyretin | 16,036 | Down | Unknown | Unknown |
