Fig. 1 | Scientific Reports

Fig. 1

From: Interplay of FXN expression and lipolysis in white adipocytes plays a critical role in insulin sensitivity in Friedreich’s ataxia mouse model

Fig. 1

Lipolysis is most affected in adipose tissue of FXN-deficient mice YG8R, associated with insulin resistance. (A–H) Y47 and YG8R male mice at 40 weeks old, fed with a standard chow diet (n = 6). (A,B) Fasting plasma glucose (A) and fasting insulin levels (B). (C) Calculated HOME-IR values based on fasting plasma glucose and fasting insulin levels. (D) Insulin tolerance tests (ITT) to show the levels of blood glucose following insulin administration. (E) The total and phosphorylated Akt (s473). Five minutes after intraperitoneal insulin injection, mice were sacrificed to harvest eWAT and examined by western blot. (F,G) Expression of genes related to lipolysis, lipogenesis, and fatty-acid β-oxidation in eWAT (F) and iWAT (G). (H,I) Representative WAT and their weights of the fat pads. (J) TAG contents in eWAT and iWAT. iWAT inguinal white adipose tissue, eWAT epididymal white adipose tissue, BAT brown adipose tissue. Values are shown as mean ± SD. t-test was used for significance. *P < 0.05, **P < 0.01, ***P < 0.001.

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