Fig. 3 | Scientific Reports

Fig. 3

From: Interplay of FXN expression and lipolysis in white adipocytes plays a critical role in insulin sensitivity in Friedreich’s ataxia mouse model

Fig. 3

FXN deficiency induces adipocyte hypertrophic expansion and increases inflammation in WAT. (A–H) Y47 and YG8R male mice at 40 weeks old were fed a normal chow (n = 6). (A) Representative H&E stained eWAT and iWAT. Scale bars, 50 μm. (B,C) Size distribution patterns of eWAT and iWAT adipocytes and quantification of adipocyte sizes. (D) Representative images for F4/80 immunohistochemistry (IHC) staining on BAT, eWAT, and iWAT and quantification on the right. Scale bar, 20 μm. (E–G) Expression of pro-inflammatory genes in BAT (E), eWAT (F), and iWAT (G). (H) Relative fold change of MDA in BAT, eWAT, and iWAT. TAG triglyceride. MDA malondialdehyde. Data were normalized to the Y47 mice group. Values are shown as mean ± SD. t-test was used for significance. *P < 0.05, **P < 0.01, ***P < 0.001.

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