Fig. 6 | Scientific Reports

Fig. 6

From: Interplay of FXN expression and lipolysis in white adipocytes plays a critical role in insulin sensitivity in Friedreich’s ataxia mouse model

Fig. 6

FXN deficiency aggravates diet-induced obesity, insulin resistance, and liver steatosis. (A–L), Y47 and YG8R male mice at 8 weeks old were fed with high fat diet (HFD) for 12 weeks (n = 6). The mice were euthanized after fasting for 18 h. (A) Body weights. (B) Weights of fat pads. (C) TAG contents in eWAT and iWAT. (D) Representative H&E stained eWAT. Scale bars, 200 μm. (E,F) Proportion distribution and sizes of adipocytes. (G,H) Serum glycerol and FFAs. (I) Representative H&E-stained liver to show the steatosis. Scale bars, 50 μm. (J) Weights of liver. (K) TAG contents in the liver. (L) GTT to show the levels of blood glucose following a-bolus-of-glucose administration. Data were normalized to the Y47 mice. Values are shown as mean ± SD. t-test was used for significance. *P < 0.05, **P < 0.01, ***P < 0.001.

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