Fig. 7 | Scientific Reports

Fig. 7

From: Interplay of FXN expression and lipolysis in white adipocytes plays a critical role in insulin sensitivity in Friedreich’s ataxia mouse model

Fig. 7

PGZ treatment improves glucose metabolism in YG8R mice by enhancing adipose tissue lipolysis capacity. (A–J) Y47 and YG8R mice at 32 weeks old were treated with PGZ (25 mg/kg/d; oral administration by gavage) for 8 weeks (n = 6). (A) Body weights. (B) GTT to show the levels of blood glucose following a-bolus-of-glucose administration. (C) ITT to show the levels of blood glucose following insulin administration. (D,E) Serum glycerol and FFAs. (F,G) Weights of iWAT and eWAT. (H) Representative H&E stained eWAT. Scale bars, 100 μm. (I) Quantification of adipocyte sizes. (J) TAG contents in eWAT. PGZ Pioglitazone. Values are shown as mean ± SD. t-test was used for significance. *P < 0.05, **P < 0.01, ***P < 0.001.

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