Fig. 2
(a) DWI (b = 800 s/mm2); (b) DWI with ROIs for tumor (red overlay) and healthy tissue (blue overlay); (c) apparent diffusion coefficient (ADC), of a representative patient (Male, 15 years) with osteosarcoma in right femur at time-points t0. IVIM parametric maps estimated by five IVIM analysis methodologies (1) Bi-exponential (BE) method with three-parameter fitting (BE), (2) Segmented BE with two-parameter fitting (BESeg-2), (3) Segmented BE with one-parameter fitting (BESeg-1), (4) BE with adaptive Total-Variation penalty (BE + TV) and (5) BE with adaptive Huber penalty (BE + HPF) at time-points t0 are depicted in (d–h) Diffusion coefficient (D), (i–m) Perfusion coefficient (D*) and (n–r) Perfusion fraction (f) respectively. Red, yellow and white arrows indicate the tumor regions in D, D* and f maps respectively.
