Fig. 4
From: The molecular basis of the anticancer effect of statins
Graphical description of the filtering process applied during the identification of best candidates. (a) Through the implementation of statistically determined scoring thresholds (DScore > 0.35, SLScore > 0.5, GScore > 0.35), we have identified a subset of candidates exhibiting superior promise. This has resulted in a pool of 219 best candidates, represented by blue triangles. Within this pool, the number of repurposable drugs is further refined to 97, distinctly visualized as red dots. (b) Among the 219 best candidates, 55.7% have already received approval for use in cancer treatment, while 44.3% are commercially available drugs currently used for non-cancer treatments but show potential for repurposing in cancer therapy.
