Table 2 The two tables show the computational findings pertaining to the (a) HDAC2 and (b) HMGCR genes, and their corresponding Synthetic Lethality pairments with deleted metastatic genes, which are inhibited by drugs of the statin family (Atorvastatin, Lovastatin, Simvastatin, Pravastatin). The SL pairs that we selected for experimental validation are highlighted in bold.
From: The molecular basis of the anticancer effect of statins
Mutated gene | Target gene |
|---|---|
(a) | |
BRAF | HDAC2 |
BRCA1 | HDAC2 |
SMARC4 | HDAC2 |
VHL | HDAC2 |
(b) | |
ATM | HMGCR |
CDK12 | HMGCR |
ERBB3 | HMGCR |
FGFR4 | HMGCR |
KRAS | HMGCR |
PRKDC | HMGCR |
