Table 3 Sensitivity to Simvastatin and Lovastatin of cell lines harboring genes that are mutated and in Synthetic Lethality pairs. The table reports the specific mutated genes for each cell lines treated with Simvastatin or Lovastatin, along with the corresponding IC50 values identified.
From: The molecular basis of the anticancer effect of statins
Cancer type | Cell line | Mutated gene | Target gene | Simvastatin IC50 (µM) | Lovastatin IC50 (nM) |
|---|---|---|---|---|---|
Breast | MDA-MB-231 | KRAS | HMGCR | 2.108 | 9.5 |
Breast | HCC1937 | BRCA1 | HDAC2 | 20.94 | 8700 |
Ovarian | OVPA8 | BRCA1 | HDAC2 | 8 | 522 |
Cervix | HeLa | – | – | No effect | No effect |
