Fig. 4
From: Microglial process convergence onto injured axonal swellings, a human postmortem brain tissue study
Injured axons have lower perimeters and are more circular than MBP + intact myelinated fibers. Low magnification micrographs of MBP + intact myelinated fibers (arrow heads) within and APP + axonal swellings (arrows) within (A) control tissue or (B) DAI tissue. Box and whisker plots of (C) the perimeter of axonal segments and D) the circularity of axonal segments of MBP + intact axonal fibers in either control cases (n = 161 fibers) or TBI cases (n = 36 fibers) and APP + injured axonal swellings in control cases (n = 105 swellings) or TBI cases (n = 173 swellings). Note that while there was no significant difference between APP + axonal swellings in control tissue compared to MBP + myelinated fibers in control tissue (p = 0.08), injured APP + axonal swellings within TBI tissue had significantly lower perimeters. Scale bar is 20 μm. *p < 0.05.
