Table 1 Homologies of HA/NA genes (ORF) between GD strains and vaccine strains (VSs).

From: The evolutionary features and roles of single nucleotide variants and charged amino acid mutations in influenza outbreaks during NPI period

Gene

Item

Year

No

Homology (%)a

Bri/60/08 (2008 VS)

Col/6/17 (2017 VS)

Was/2/19 (2019 VS)

Aus/1359417/21 (2021 VS)

HA

Data

2019

16

98.26 ± 0.17

99.00 ± 0.16

99.78 ± 0.18

98.51 ± 0.09

2020

9

98.25 ± 0.08

98.93 ± 0.50

99.80 ± 0.07

98.47 ± 0.05

2021

34

97.88 ± 0.16

98.58 ± 0.18

98.87 ± 0.18

99.22 ± 0.24

2022

13

97.74 ± 0.12

98.43 ± 0.13

98.73 ± 0.13

99.23 ± 0.22

Statisticb

ANOVA

F = 46.70, P < 0.001

F = 43.95, P < 0.001

F = 186.45, P < 0.001

F = 74.78, P < 0.001

Student–Newman–Keuls

Sebset 1: 2019, 2020

Sebset 1: 2019, 2020

Sebset 1: 2019, 2020

Sebset 1: 2019, 2020

Sebset 2: 2021

Sebset 2: 2021

Sebset 2: 2021

Sebset 2: 2021, 2022

Sebset 3: 2022

Sebset 3: 2022

Sebset 3: 2022

 

NA

Data

2019

16

98.55 ± 0.16

99.27 ± 0.16

99.85 ± 0.14

98.55 ± 0.16

2020

9

98.45 ± 0.10

99.17 ± 0.10

99.81 ± 0.10

98.45 ± 0.10

2021

34

98.49 ± 0.10

99.21 ± 0.10

99.28 ± 0.10

98.57 ± 0.15

2022

13

98.37 ± 0.12

99.06 ± 0.10

99.13 ± 0.10

98.43 ± 0.13

Statistic

ANOVA

F = 6.23, P = 0.01

F = 7.75, P < 0.001

F = 158.5, P < 0.001

F = 3.93, P = 0.012

Student–Newman–Keuls

Sebset 1: 19, 20, 21

Sebset 1: 19, 20, 21

Sebset 1: 2019, 2020

Only Sebset 1

Sebset 2: 20, 22

Sebset 2: 2022

Sebset 2: 2021

 
  

Sebset 3: 2022

 
  1. aFour reference strains were vaccine strains; bThe One-Way ANOVA using the compare means, and the Student–Newman–Keuls using the Cluster.