Fig. 6 | Scientific Reports

Fig. 6

From: Multi-modal transcriptomic analysis reveals metabolic dysregulation and immune responses in chronic obstructive pulmonary disease

Fig. 6

Feature gene correlation analysis. (A–D) detail the single-gene gene set enrichment analysis (GSEA) conducted for EP300, MTOR, NFE2L1, and TXN, respectively, with a focus on the top five pathways of highest and lowest enrichment significance. (E) Presents a GeneMANIA network diagram for these genes, featuring 20 closely related genes in the outer circle. The interconnecting lines represent correlations, while varied colored modules within the genes signify different enriched functional pathways. (F) Illustrates a heatmap of correlations among the four genes, where red and blue denote positive and negative correlations, respectively, and circle size and color intensity reflect the strength of the correlation. (G–J) depict box plots showing the differential expression of each gene in Control and COPD. The range of the box plots indicates gene expression variability, with the black line representing the mean value. Statistical significance is denoted by p-values between the box plots, with P < 0.05 indicating significance. Asterisks represent varying levels of statistical significance: *P < 0.05, **P < 0.01, ***P < 0.001.

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