Fig. 7 | Scientific Reports

Fig. 7

From: Multi-modal transcriptomic analysis reveals metabolic dysregulation and immune responses in chronic obstructive pulmonary disease

Fig. 7

The analysis focused on immune cell infiltration differences between control and COPD subjects. (A) Features a stacked histogram depicting the proportions of 22 immune cell types infiltrating in each sample for both groups. (B) Displays a heatmap representing the correlation between these 22 immune cells, with purple indicating positive correlation and green signaling negative correlation; the values in the heatmap correspond to the magnitude of these correlations. (C) Introduces a box line plot to illustrate the variation in infiltration levels of the 22 immune cells between the Control and COPD groups. (D) Presents another heatmap, this time delineating the correlations between the four feature genes (EP300, MTOR, NFE2L1, TXN) and the 22 types of immune cells, providing a nuanced understanding of gene-immune interactions in COPD. Statistical significance in these correlations is indicated by asterisks: *P < 0.05, **P < 0.01, ***P < 0.001.

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