Fig. 6
From: Microvascular and cellular dysfunctions in Alzheimer’s disease: an integrative analysis perspective
Differential gene pathway analysis. (A) Pathway enrichment analysis showed that pericytes’ downregulated genes in AD were enriched in the PI3K–AKT pathway; (B) Enrichment analysis for downregulated genes primarily identifies significant enrichment in pathways associated with vascular transport, transport across the blood–brain barrier (BBB), and the extracellular matrix (ECM). (C) GSVA showed that PI3K–AKT pathway activity was significantly downregulated in pericytes of AD.
