Fig. 7

(A) The PI3K–AKT pathway was central in the construction of the pericytes differential gene module; (B) Key genes related to the PI3K–AKT pathway were significantly downregulated in the pericytes of AD patients; (C) SCENIC transcription factor prediction analysis showed that the activity of FOXO1/4/6 was significantly upregulated in the pericytes of AD; (D) Schematic diagram of the PI3K–AKT–FOXO pathway; (−p: dephosphorylation process; +p: phosphorylation process) (E) GSVA analysis of hippocampal and cortical pericytes revealed differences in pathway activity between the AD and normal groups; (F) GSVA analysis indicated that hippocampal immune-related pathway activity in AD was significantly higher than in the cortex, whereas the activity levels of the PI3K–AKT, FOXO, and cell cycle pathways were significantly lower than those in the cortex. (p < 0.05 was considered statistically significant.)