Fig. 4 | Scientific Reports

Fig. 4

From: Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway

Fig. 4

Schematic model illustrating the potential pathway associated with morphine-induced malignant biological behaviour in A549 cells. Morphine acts on an MOR located on the A549 cell membrane, leading to increased levels of phospho-PI3K and phospho-AKT. The activation of the PI3K/AKT pathway further activates mTOR, may be leading to the downregulation of E-cadherin, which induces cell proliferation, migration and invasion.

Back to article page