Table 1 miRNA expression in decompensated cirrhosis states and HC/cCLD.

From: microRNA associated with hepatocyte injury and systemic inflammation may predict adverse outcomes in cirrhotic patients

miRNA

N

Decompensated (n = 134)

N

cCLD/HC (n = 40)

p value

AUC

(A)

 miR-103a

134

298.72 (2.36)

40

298.39 (2.07)

0.43

 

 miR-122

134

278.29 (12.02)

40

272.35 (15.73)

0.01*

0.62 (0.51–0.73)

 miR-150

134

280.95 (7.97)

40

280.56 (9.15)

0.79

 

 miR-16-2

134

269.62 (9.15)

39

269.15 (9.51)

0.78

 

 miR-17

113

243.87 (11.45)

36

246.23 (13.34)

0.30

 

 miR-191

131

295.54 (1.10)

39

295.37 (1.14)

0.40

 

 miR-200b

19

236.38 (23.35)

5

224.04 (25.23)

0.31

 

 miR-20a

101

247.91 (6.86)

35

249.25 (4.83)

0.29

 

 miR-223

134

310.35 (1.78)

40

311.09 (1.58)

0.02*

0.63 (0.53–0.73)

 miR-23a

134

302.94 (1.55)

40

302.90 (1.86)

0.90

 

 miR-24

134

302.60 (1.80)

40

301.89 (1.90)

0.03*

0.62 (0.52–0.73)

 miR-25

134

299.73 (6.30)

40

297.51 (6.85)

0.06

 

 miR-26a

134

296.91 (1.68)

40

297.28 (1.76)

0.22

 

 miR-27a

134

294.65 (2.08)

40

295.69 (1.81)

0.005*

0.67 (0.58–0.76)

 miR-29b

134

261.77 (8.68)

40

266.01 (6.86)

0.005*

0.65 (0.56–0.74)

 miR-30a

134

272.43 (8.27)

40

268.23 (11.14)

0.01*

0.63 (0.52–0.74)

 miR-330

45

226.72 (12.69)

19

216.51 (14.51)

0.006*

0.72 (0.58–0.87)

 miR-451a

134

321.18 (6.02)

40

321.16 (6.02)

0.99

 

 miR-503

102

251.84 (7.58)

35

249.04 (7.09)

0.06

 

 miR-663

9

231.85 (19.60)

3

192.46 (35.28)

0.03*

0.85 (0.62–1.00)

miRNA

Decompensated (n = 134)

Compensated (n = 40)

p value

   

(B)

 miR-149

2 (1.49%)

0 (0.00%)

 > 0.9999

   

 miR-17

113 (84.33%)

36 (90%)

0.45

   

 miR-200b

19 (14.18%)

5 (12.50%)

 > 0.9999

   

 miR-20a

101 (75.4%)

35 (87.50%)

0.13

   

 miR-330

45 (33.58%)

19 (47.5%)

0.14

   

 miR-503

102 (76.12%)

35 (87.50%)

0.19

   

 miR-663

9 (6.72%)

3 (7.50%)

 > 0.9999

   

miRNA

β value

OR

p value

   

(C)

 miR-24

0.6491

1.91 (1.45–2.62)

 < 0.0001*

   

 miR-27a

− 0.6201

0.54 (0.41–0.69)

 < 0.0001*

   
  1. (A) Results of t tests between patients with decompensated CLD states and HC/cCLD. Results given as mean (SD). If p < 0.05, AUC was calculated. (B) For miRNA detected in < 85% of samples, reanalysis was performed after converting results to either detected (1) or undetected (0) using Fisher’s exact test. Results given as number (%). (C) miRNA model utilized to distinguish decompensated CLD (n = 174, AUC 0.77 (95% CI 0.69-0.85, p < 0.0001*); pseudo r2 = 0.1849, HL stat 8.95 (p = 0.35). Statistical significance set after correction for false discovery with the Benjamini-Hochberg procedure (p < 0.0344) and designated by *.
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