Table 3 One year risk of mortality/LT and competing risk analysis for 1 year risk of LT.

From: microRNA associated with hepatocyte injury and systemic inflammation may predict adverse outcomes in cirrhotic patients

microRNA

N

HR (95% CI)

C-statistic (95% CI)

(A)

 miR-103a

154

1.03 (0.94–1.15)

 

 miR-122

154

0.99 (0.98–1.01)

 

 D/ND miR-149

154

1.02 (0.06–4.61)

 

 miR-150

154

1.00 (0.98–1.03)

 

 miR-16-2

153

1.02 (0.996–1.05)

 

 miR-17

129

1.01 (0.99–1.03)

 

 D/ND miR-17

154

0.63 (0.37–1.14)

 

 miR-191

151

1.21 (0.99–1.47)

 

 D/ND miR-200b

154

1.68 (0.87–3.03)

 

 miR-20a

116

0.81 (0.50–1.37)

 

 D/ND miR-20a

154

1.24 (0.73–2.02)

 

 miR-223

154

1.05 (0.93–1.19)

 

 miR-23a

154

1.04 (0.91–1.17)

 

 miR-24

154

1.08 (0.97–1.20)

 

 miR-25

154

1.03 (0.999–1.07)

 

 miR-26a

154

0.90 (0.79–1.03)

 

 miR-27a

154

0.98 (0.88–1.09)

 

 miR-29b

154

0.99 (0.97–1.02)

 

 miR-30a

154

1.01 (0.99–1.04)

 

 miR-330

54

1.05 (1.01–1.09)

0.67 (0.54–0.80)

 D/ND miR-330

154

0.59 (0.34–0.96)

0.56 (0.51–0.61)

 miR-451

154

1.03 (0.99–1.07)

 

 miR-503

117

1.01 (0.97–1.05)

 

 D/ND miR-503

154

0.84 (0.51–1.43)

 

 D/ND miR-663

154

0.81 (0.25–1.97)

 

microRNA

aHR (95% CI)

  

(B)

 D/ND miR-330 with MELD

0.66 (0.38–1.09)

  

 D/ND miR-330 with CP

0.71 (0.41–1.17)

  

microRNA

N

SHR (95% CI)

 

(C)

 miR-103a

154

1.03 (0.93–1.15)

 

 miR-122

154

0.99 (0.97–1.01)

 

 D/ND miR-149

154

1.94 (0.29–12.99)

 

 miR-150

154

0.98 (0.95–1.01)

 

 miR-16-2

153

1.02 (0.99–1.05)

 

 miR-17

129

1.01 (0.98–1.04)

 

 D/ND miR-17

154

0.77 (0.38–1.58)

 

 miR-191

151

1.00 (0.79–1.28)

 

 D/ND miR-200b

154

1.59 (0.73–3.47)

 

 miR-20a

116

0.97 (0.93–1.02)

 

 D/ND miR-20a

154

0.57 (0.31–1.03)

 

 miR-223

154

0.94 (0.81–1.09)

 

 miR-23a

154

0.92 (0.79–1.07)

 

 miR-24

154

0.98 (0.85–1.13)

 

 miR-25

154

1.02 (0.98–1.07)

 

 miR-26a

154

1.03 (0.88–1.20)

 

 miR-27a

154

0.93 (0.83–1.05)

 

 miR-29b

154

0.98 (0.94–1.01)

 

 miR-30a

154

1.00 (0.97–1.03)

 

 miR-330

54

1.02 (0.98–1.06)

 

 D/ND miR-330

154

0.75 (0.41–1.39)

 

 miR-451

154

1.02 (0.97–1.07)

 

 miR-503

117

1.02 (0.97–1.08)

 

 D/ND miR-503

154

0.75 (0.40–1.43)

 

 D/ND miR-663

154

1.02 (0.31–3.32)

 
  1. (A) One year risk of mortality/LT and association with microRNA expression. For microRNA with significant HR, C-statistic is calculated. (B) D/ND miR-330 adjusted for MELD (MELD score performance n = 151, C-statistic = 0.69 (95% CI 0.63-0.75)) and CP (CP score performance n = 151, C-statistic = 0.69 (95% CI 0.63-0.75)). (C) Competing risk analysis for 1 year risk of LT. D/ND = microRNA converted into categorical variable and marked as detected = 1 or not detected = 0.
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