Table 4 Relationships between baseline clinical, imaging and blood biomarkers with change in myocardial perfusion reserve.

	Pearson’s Correlation co-efficient		Multivariable associations
	r (95% CI)	p-value	B (95% CI)	p-value
Age	0.03 (−0.25, 0.31)	0.816
Sex	0.13 (−0.15, 0.40)	0.356
Hypertension	−0.13 (−0.39, 0.16)	0.372
Diabetes	0.18 (−0.10, 0.44)	0.200	8.52 (−14.93,31.96)	0.468
CAD	0.03 (−0.25, 0.31)	0.828	−4.90 (−30.91, 21.11)	0.706
Log₁₀ NTproBNP	0.10 (−0.25, 0.43)	0.569
AV Vmax	0.34 (0.07, 0.56)	0.016	7.00 (−10.56, 24.47)	0.428
AV MPG	0.31 (0.03, 0.54)	0.031
AVAi	−0.29 (−0.52, −0.01)	0.043
LV EDVi	0.01 (−0.27, 0.28)	0.966
LV ESVi	0.19 (−0.09, 0.45)	0.177
LV SVi	−0.16 (−0.42, 0.12)	0.263
LV EF	−0.25 (−0.49, 0.04)	0.087	−0.87 (−2.17, 0.42)	0.181
LVMi	−0.02 (−0.30, 0.26)	0.889
LV mass: volume	−0.05 (−0.32, 0.24)	0.755
LGE	0.34 (0.06, 0.56)	0.017	5.78 (−17.46, 29.01)	0.619
Stress MBF	−0.31 (−0.54, −0.03)	0.029
Rest MBF	0.13 (−0.15, 0.40)	0.353
MPR	−0.47 (−0.66, −0.22)	< 0.001	−23.23 (−43.11, −3.36)	0.023
	Adjusted R²		0.298	0.014

Bold p values are statistically significant.
Statistical tests: Pearson’s correlation to investigate associations between baseline variables and change in MPR.
Multivariable linear regression to determine the associations with change in MPR.
AV, aortic valve; AVAi, aortic valve area indexed to BSA; CAD, coronary artery disease; EDVi, end diastolic volume indexed, ESVi, end systolic volume indexed; EF, ejection fraction; LGE, late gadolinium enhancement; LV, left ventricle; LVMi, left ventricular mass indexed; MBF, myocardial blood flow; MPR, myocardial perfusion reserve; MPG, mean pressure gradient; NTproBNP, N-terminal pro-brain natriuretic peptide; SVi, stroke volume indexed; Vmax, peak velocity.

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