Fig. 1

Analysis of ITLN1 gene expression in the LOBB cross-sectional cohort (CSC). (A) Comparison of ITLN1 expression between patients with and without obesity for subcutaneous and visceral adipose tissue (VAT and SAT respectively). (B) Analogous comparison for females and males. (C) Correlation of ITLN1 gene expression with clinical parameters including all CSC patients, separately for females (F), and separately for males (M). (D) Scatter plot of the correlation of body fat with ITLN1 expression measured VAT for all probands, and (E) in VAT for females. Shown in (F) is correlation of males’ VAT ITLN1 expression with serum leptin, (G) Cholesterol, and (H) LDL-Cholsterol. We used Kruskal–Wallis one-way ANOVAs and the Mann–Whitney U test for pairwise comparisons among violin plots and corrected for multiple comparisons using the Hommel method. Correlations in boxplots are FDR-adjusted Spearman’s correlation coefficients. P-value symbols and significance: *** p < 0.001; ** p < 0.01; * p < 0.05; ### comparisons with the other tissue groups are all significant (p < 0.001).