Fig. 3 | Scientific Reports

Fig. 3

From: Expression of Intelectin-1, also known as Omentin-1, is related to clinical phenotypes such as overweight, obesity, insulin resistance, and changes after bariatric surgery

Fig. 3

ITLN1 gene expression among the MHO/MUO cohort, in people with metabolically healthy, insulin sensitive (IS) versus metabolically unhealthy, insulin resistant (IR) obesity. (A) Comparison of ITLN1 expression between insulin resistant (IR) and insulin sensitive (IS) persons for SC and VAT. (B) Correlation of ITLN1 gene expression in VIS and SAT with a comprehensive set of clinical parameters including all insulin-resistant (IR) or insulin-sensitive (IS) persons among the MHO/MUO as well as in female (F) and male (M) subsets. (C) Scatterplot of FDR-adjusted Spearman’s correlation between ITLN1 expression and progranulin in VAT of IR males. Spearman’s correlation coefficient and FDR-adjusted for multiple testing. Inset (D) Analysis of ITLN1 gene expression within the two-step bariatric surgery cohort (BSC). Comparison of ITLN1 expression between the time point of first surgery and second step surgery after significant weight loss for SC and VAT. Kruskal–Wallis one-way ANOVA was performed, and the Mann–Whitney U test was used for pairwise comparisons, corrected for multiple comparisons using the Hommel method. P-value symbols and significance: *** p < 0.001; ** p < 0.01; * p < 0.05; ### comparisons with the other tissue groups are all significant (p < 0.001).

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