Fig. 3 | Scientific Reports

Fig. 3

From: CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC)

Fig. 3

The effects of hyperthermic chemotherapy on colorectal cancer cell-lines and on patient derived tumor organoids. (a) MHC-I expression on treated HCT-8 cells. (b)The heat-map shows the expression profile of nine different CTAs of untreated and treated HCT-8 cell-line samples. (c and d). The fold induction of Cyclin A1 and SSX-4 expression. (e and f) Western Blot for Cyclin A1 and the quantification of the protein expression. The original blots are presented in Supplementary Fig. 8. (g) CTA expression of four different patient derived tumor organoids after Oxaliplatin treatment. The experiments were performed in triplicates. One representative experiment out of three is shown. Error bars show the mean +/-SD. **** = p ≤ 0.0001, *** = p ≤ 0.001, ** = = p ≤ 0.01, * = p ≤ 0.05, ns = p > 0.05.

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