Fig. 12
From: Persistence of post-stress blood pressure elevation requires activation of astrocytes
Changes in mean arterial blood pressure (MAP). (a) Time course of MAP before, during, and after stress loading. MAP values obtained from all tested rats were averaged and normalized to baseline (MAP recorded for 2.5 min before stress loading) and set as 100%. Stress-induced blood pressure elevation during and after stress loading was suppressed by prior administration of arundic acid in a dose-dependent manner. (b) Average change in MAP (ΔMAP) during air-jet stress (left) and post-stress (right) periods compared to the pre-stress resting state. ΔMAP during stress was significantly diminished by arundic acid pre-treatment in a dose-dependent manner. Although ΔMAP during the post-stress period remained positive under the control condition, it decreased and became negative with arundic acid pre-treatment in a dose-dependent manner. Data are presented as means ± SE, n = 13 per group. *Bonferroni corrected, p < 0.05 vs. control group.
