Fig. 1 | Scientific Reports

Fig. 1

From: Validation of a functional human AD model with four AD therapeutics utilizing patterned ipsc-derived cortical neurons integrated with microelectrode arrays

Fig. 1

Morphology of patterned cortical neurons on MEAs and expression of the molecular targets of AD drugs in hiPSC-derived cortical neurons. Phase images of hiPSC-derived cortical neurons distributed on patterns aligned with MEA electrodes (A,B,E), scale bar = 100 μm. (C,D,F,G,H) Immunocytochemistry of hiPSC-derived cortical neurons utilizing antibodies specific to target proteins relevant for AD drugs revealed the cells expressed all markers evaluated: Fyn (green in C), nAChR (red in D), PDE4 (green in F), AChE (green in G), NMDR (green in H). Neurons were co-stained with the neuronal marker MAP2 and Dapi in all these images. Scale bar 50 μm.

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