Table 2 Baseline characteristics of endotracheal and intranasal doses.
ETT | p-value | IN | p-value | |||||
|---|---|---|---|---|---|---|---|---|
Vaso 4 (n = 5) | Vaso 8 (n = 5) | Vaso 16 (n = 5) | Vaso 8 (n = 3) | Vaso 16 (n = 3) | Vaso 32 (n = 3) | |||
Age (days) | 2 (1–2) | 1 (1–2) | 2 (1–2) | 0.77 | 3 (2–3) | 2 (1–2) | 1 (1–3) | 0.30 |
Weight (kg) | 1.9 (1.8–1.9) | 1.8 (1.8–2) | 2 (1.8–2.1) | 0.67 | 2.3 (2–2.3) | 2.1 (1.8–2.2) | 2 (1.9–2.1) | 0.35 |
Sex (male/female) | 2/2 | 4/1 | 4/1 | 0.59 | 2/1 | 3/0 | 2/1 | 0.63 |
pH | 7.433 (7.427–7.448) | 7.479 (7.449–7.492) | 7.488 (7.429–7.5) | 0.79 | 7.491 (7.411– 7.496) | 7.531 (7.53–7.56) | 7.484 (7.474–7.508) | 0.06 |
paCO2 (torr) | 34.5 (32.7–36.7) | 33.6 (31.4–35.3) | 32.7 (31.9–34.9) | 0.80 | 30.8 (30.3–37.5) | 29 (28.1–30.5) | 31.3 (30.9–39) | 0.33 |
paO2 (torr) | 74.8 (69.2–79.1) | 83.4 (77.6–86.1) | 75.2 (71.1–79.9) | 0.10 | 83.5 (70.1–92.9) | 79.8 (73.3–90.4) | 74.7 (61.4–83) | 0.53 |
Base excess (mmol/L) | -1 (-1.2~ -0.1) | -0.1 (-0.6 ~ 2.6) | 1.7 (-1.3 ~ 3.1) | 0.80 | 0.2 (-0.8 ~ 0.3) | 2.8 (0.8 ~ 3.8) | 1.8 (-0.2 ~ 5) | 0.23 |
Lactate (mmol/L) | 4.25 (4.2–5.06) | 3.81 (2.94–4.29) | 4.57 (4.23–4.58) | 0.78 | 4.25 (3.56–5.05) | 4.26 (3.81–4.86) | 4.31 (3.9–4.93) | 0.98 |
Hemoglobin (g/0.1 L) | 7.9 (7–8) | 8.2 (8–9.6) | 7.9 (7.8–9.7) | 0.80 | 8.4 (6.8–8.6) | 8.2 (8.2–9.8) | 6.8 (6.5–8.1) | 0.19 |
Heart rate (bpm) | 163 (158–175) | 137 (122–138) | 167 (122–192) | 0.43 | 166 (129–180) | 156 (155–166) | 143 (134–150) | 0.42 |
Mean arterial pressure (mmHg) | 67 (64–68) | 53 (48–58) | 53 (51–58) | 0.009 | 64 (61–66) | 61 (58–65) | 60 (53–61) | 0.22 |
Carotid blood flow (mL/kg/min) | 83 (76–87) | 56 (53–64) | 63 (58–68) | 0.30 | 62 (49–74) | 70 (63–71) | 60 (53–72) | 0.66 |
Cardiac output (mL/kg/min) | 384 (380–384) | 290 (222–322) | 320 (311–326) | 0.32 | 259.05 (219.3–298.8) | 514.7 (465–564.4) | 375.2 (300.3–495) | 0.09 |
Ejection fraction (%) | 36 (27–37) | 41 (35–45) | 29 (28–33) | 0.14 | 40 (28.7–51.3) | 37.1 (32.6–41.6) | 28.1 (24.5–59.7) | 0.98 |
Stroke volume (mL/kg/min) | 2.51 (1.72–2.9) | 2.04 (1.92–2.1) | 2.24 (1.81–2.43) | 0.65 | 1.75 (1.7–1.8) | 3.2 (3–3.4) | 2.8 (2.1–3.3) | 0.07 |
dp/dt max (mmHg) | 2943 (2611–3742) | 2278 (2212–2671) | 2262 (2248–3224) | 0.37 | 2727 (2239–3215) | 2670.5 (2634–2707) | 2530 (220.1–2584) | 0.68 |
dp/dt min (mmHg) | -3526 (-4393~ -3380) | -3230 (-3339~ -3077) | -3275 (-3816~ -2587) | 0.40 | -3301 (-3684~ -2918) | -3832 (-4182~ -3482) | -3357 (-3540~ -3169) | 0.40 |
