Table 2 CT radiological features of training, validation and testing datasets in two groups.
Characteristic | Training cohort N = 440 | Validation cohort N = 110 | Testing cohor N = 278 | Overall N = 828 | ||||||
---|---|---|---|---|---|---|---|---|---|---|
NSMPP N = 299(68%) | SMPP N = 141(32%) | p-value1 | NSMPP N = 75(68%) | SMPP N = 35(32%) | p-value1 | NSMPP N = 224(81%) | NSMPP N = 54(19%) | p-value1 | p-value1 | |
Lobar atelectasis | 25 (8.4%) | 26(18.4%) | 0.002 | 3 (4.0%) | 6 (17.1%) | 0.028 | 17 (7.6%) | 9 (16.7%) | 0.040 | 0.83 |
Consolidation pattern | < 0.001 | 0.005 | < 0.001 | < 0.001 | ||||||
Patchy | 69 (23.1%) | 23 (16.3%) | 16 (21.3%) | 8 (22.9%) | 70 (31.3%) | 11 (20.4%) | ||||
Segmental | 58 (19.4%) | 39 (27.7%) | 21 (28.0%) | 10 (28.6%) | 67 (29.9%) | 14 (25.9%) | ||||
Wedge-shaped | 43 (14.4%) | 44 (31.2%) | 6 (8.0%) | 11 (31.4%) | 40 (17.9%) | 26 (48.1%) | ||||
Consolidation mixed GGO | 85 (28.4%) | 52 (36.9%) | 0.074 | 18 (24.0%) | 12 (34.3%) | 0.26 | 111(49.6%) | 39 (72.2%) | 0.003 | < 0.001 |
Adjacent pleura thickening | 69 (23.1%) | 51 (36.2%) | 0.004 | 20 (26.7%) | 15 (42.9%) | 0.089 | 7 (3.1%) | 5 (9.3%) | 0.061 | < 0.001 |
Pleural effusion | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||||||
Small | 21 (7.0%) | 30 (21.3%) | 4 (5.3%) | 12 (34.3%) | 6 (2.7%) | 9 (16.7%) | ||||
Moderate | 7 (2.3%) | 15 (10.6%) | 1 (1.3%) | 0 (0.0%) | 1 (0.4%) | 1 (1.9%) | ||||
Large | 5 (1.7%) | 8 (5.7%) | 1 (1.3%) | 1 (2.9%) | 2 (0.9%) | 1 (1.9%) | ||||
Mediastinal enlargement of lymph nodes | 33 (11.0%) | 32 (22.7%) | 0.001 | 9 (12.0%) | 8 (22.9%) | 0.14 | 18 (8.0%) | 3 (5.6%) | 0.77 | 0.010 |
Air bronchogram sign | 92 (30.8%) | 70 (49.6%) | < 0.001 | 24 (32.0%) | 18 (51.4%) | 0.051 | 127 (56.7%) | 46 (85.2%) | < 0.001 | < 0.001 |
Interlobular septal thickening | 72 (24.1%) | 51 (36.2%) | 0.008 | 14 (18.7%) | 11 (31.4%) | 0.14 | 30 (13.4%) | 12 (22.2%) | 0.10 | < 0.001 |
Reticular pattern | 32 (10.7%) | 26 (18.4%) | 0.025 | 5 (6.7%) | 5 (14.3%) | 0.28 | 20 (8.9%) | 7 (13.0%) | 0.37 | 0.26 |
Fiber cords | 183 (61.2%) | 105 (74.5%) | 0.006 | 57 (76.0%) | 23 (65.7%) | 0.26 | 54 (24.1%) | 13 (24.1%) | > 0.99 | < 0.001 |
Number of lobes involved | < 0.001 | 0.65 | 0.53 | < 0.001 | ||||||
1 | 143(47.8%) | 51 (36.2%) | 28(37.3%) | 12(34.3%) | 79 (35.3%) | 18 (33.3%) | ||||
2 | 42 (14.0%) | 10 (7.1%) | 11 (14.7%) | 2 (5.7%) | 49 (21.9%) | 9 (16.7%) | ||||
3 | 36 (12.0%) | 12 (8.5%) | 11 (14.7%) | 6 (17.1%) | 36 (16.1%) | 8 (14.8%) | ||||
4 | 29 (9.7%) | 16 (11.3%) | 8 (10.7%) | 3 (8.6%) | 20 (8.9%) | 9 (16.7%) | ||||
5 | 49 (16.4%) | 52 (36.9%) | 17 (22.7%) | 12 (34.3%) | 40 (17.9%) | 10 (18.5%) | ||||
Average lesion density(Hu) | -511 (138) | -439 (173) | < 0.001 | -533 (135) | -388 (161) | < 0.001 | -463 (169) | -334 (192) | < 0.001 | 0.003 |
CTLP(%) | 5.84(10) | 5.76 (9) | 0.72 | 5.49 (11) | 7.87(13) | 0.29 | 0.06 (0.08) | 4.03 (9.53) | < 0.001 | < 0.001 |