Fig. 3 | Scientific Reports

Fig. 3

From: Efficacy of epidermal growth factor in suppressing inflammation and proliferation in pterygial fibroblasts through interactions with microenvironmental M1 macrophages

Fig. 3

EGF-induced attenuation of inflammatory, fibrotic, and vasculogenic signals in pterygial fibroblasts during co-culture with M1 macrophages. (A) Scheme of co-culture of M1 macrophages and pterygium fibroblasts using transwell system with EGF treatment (10 ng/mL for 24 h). (B-H) Real-time RT-PCR analysis for IL6, IL1B, MMP2, VCAM1, ICAM1, VEGFA and VEGFC expressions in pterygial fibroblast with and without EGF (10 ng/mL) during co-culture with M1 macrophages (24 h). Analysis of variance followed by Tuckey’s post-hoc test. N = 4. *p\(\:<\)0.05, **p\(\:<\)0.01, ***p\(\:<\)0.001, ****p\(\:<\)0.0001, and ns: not significant. EGF, epidermal growth factor; PF, pterygial fibroblast.

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