Table 1 Summary of how different treatments influence taurine levels and ethanol-induced taurine levels.

From: Separate mechanisms regulating accumbal taurine levels during baseline conditions and following ethanol exposure in the rat

 

Effects on taurine output

Treatment

Treatment vs. vehicle

Treatment  + EtOH vs. Treatment

Treatment  + EtOH vs. Vehicle  + EtOH

TTX

Action potential inhibition

↑

N/A

↑

Memantine

NMDAR inhibition

↑

↑

n.s.

GES

Taurine transporter inhibition

↑

n.s.

↑

DCPIB

VRAC inhibition

n.s.

n.s.

n.s.

Gi-DREADDs (inhibitory)

Activation of inhibitory receptors on astrocytes

N/A

↑

↑

Gq-DREADDs (excitatory)

Activation of excitatory receptors on astrocytes

N/A

↑

n.s.

FC

Astrocyte TCA-cycle inhibition

↑

↑

n.s.

NCD

LTCC inhibition

n.s.

n.s.

↓

  1. Comparison is made between treatment and vehicle (column 1), treatment + EtOH and treatment (column 2) and treatment + EtOH and vehicle + EtOH (column 3). EtOH = ethanol, FC = fluorocitrate, GES = guanidinoethyl sulfonate, DREADDs = designer receptors exclusively activated by designer drugs, LTCC = L-type Ca2+ channel, VRAC = volume regulated anion channels, TTX = tetrodotoxin, n.s.=non-significant.
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