Table 3 HR with 95% CI for OS in patients with EGFR-mutant NSCLC and brain metastases.

1G EGFR-TKIs

0.86 (0.45–1.64)

2G EGFR-TKIs

1.16 (0.79–1.70)

1.35 (0.64–2.85)

3G EGFR-TKIs

1.46 (1.07–1.98)*

1.69 (0.83–3.45)

1.26 (0.77–2.05)

1G EGFR-TKIs + CT

1.97 (1.14–3.40)*

2.28 (0.98–5.31)

1.69 (1.15–2.50)*

1.35 (0.72–2.52)

3G EGFR-TKIs + CT

1.28 (0.90–1.82)

1.49 (0.71–3.10)

1.10 (0.66–1.86)

0.88 (0.55–1.40)

0.65 (0.34–1.25)

1G EGFR-TKIs + VEGF mAb