Fig. 2
From: Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease
Neurons overexpressing pathogenic polyQ proteins can regenerate dendrite arbors following complete removal at 48 h AEL. (A) Schematic of uninjured neurons (purple) and bald neurons (blue). Red arrows represent 2 photon laser injury. (B) Uninjured neurons and balded neurons for WT, ATX1.82 overexpression, and MJD.78Q overexpression neurons at 24 and 72 h after injury done at 48 h AEL. Scale bar 50 μm. (C) Number of branch tips (top) and total branch length (bottom) at 24 and 72 h after injury for uninjured (purple) and balded (blue) for WT, ATX1.82Q, and MJD.78Q overexpression neurons. Individual neurons (faded) and mean (bold) values shown, with slope (m) between the mean 24 and 72 h after injury values. Paired t-test. (D) Number of branch tips (left) and total branch length (right) between uninjured and balded WT, ATX1.82Q, and MJD.78Q overexpression neurons at 72 h after injury. Welch’s t-test. See also Fig S3.
