Fig. 3
From: Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease
Injury to a single dendrite branch induces neuroprotection in neurons overexpressing pathogenic polyQ proteins. (A) Schematic of uninjured neurons (purple, UI), normalized control neurons (pink, NC), and single branch injured neurons (green, SBI). The red arrow represents 2 photon laser injury. (B, E, H, K, N) Normalized control and single branch injured neurons at 24 and 72 h after injury for WT and ATX1.82Q, ATX2.64Q, MJD.78Q, and HTT23NT.128Q overexpression neurons. Scale bar 50 μm. (C, F, I, L, O) Comparing number of branch tips and total branch length of NC and SBI neurons at 72 h after injury, or comparing % change in number of branch tips and total branch length between 24 to 72 h after injury between NC and SBI neurons. Welch’s t-test. (D, G, J, M, P) Number of branch tips and total branch length at 24 and 72 h after injury for NC (pink) and SBI (green) neurons. Individual neurons are faded, solid lines represent the average slope (m) between the mean 24 and 72 h after injury values. Paired t-test. See also Fig S4–S8.
