Table 3 Clinicopathological characteristics of luminal breast cancer patients according to pS6 level.

From: Higher risk of recurrence in early-stage breast cancer patients with increased levels of ribosomal protein S6

Characteristics

Low pS6

(n = 101)

High pS6

(n = 28)

p-value

Age (mean ± SD, years)

53.54 ± 11.48

53.43 ± 12.92

0.9

Histologic subtype (n (%))

Ductal

69 (68.3)

26 (92.9)

0.07

Lobular

17 (16.8)

1 (3.6)

Ductal-lobular

11 (10.9)

1 (3.6)

Others

4 (4.0)

0 (0.0)

Ki67 (median [IQR], %)

9.00 [5.00, 17.75]

14.50 [4.75, 30.50]

0.2

Tumor size (median [IQR], cm)

3.00 [2.00, 5.00]

4.00 [2.50, 7.00]

0.06

Lymph nodes

(n (%))

Negative

36 (35.6)

8 (28.6)

0.6

Positive

63 (62.4)

20 (71.4)

Unknown

2 (2.0)

0 (0.0)

Stage (n (%))

I

19 (18.8)

3 (10.7)

0.1

II

46 (45.5)

9 (32.1)

III

36 (35.6)

16 (57.1)

Nottingham grade (n (%))

1

28 (27.7)

2 (7.1)

0.04 *

2

50 (49.5)

13 (46.4)

3

13 (12.9)

7 (25.0)

Unknown

10 (9.9)

6 (21.4)

Recurrence

(n (%))

No

87 (86.1)

12 (42.9)

< 0.001 *

Yes

14 (13.9)

16 (57.1)

  1. Values are presented as n (%), mean ± SD or median [IQR], as appropriate. pS6 level represents the percentage of pS6 positive tumor cells, and the cutoff was determined as 42.5%. Recurrence was analyzed within a median follow-up time of 53 months. Other subtypes included papillary (n = 3) and micropapillary (n = 1) carcinomas. *p < 0.05, using the Chi-squared test for categorical variables, and the one-way ANOVA test or Mann-Whitney U test for normal and non-normal continuous variables, respectively. Unknown data were excluded from the statistical analysis. SD: standard deviation; IQR: interquartile range.
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