Fig. 1

The structure of kinase domain and key structural elements. The active state (DFGin-BLAminus) of BRAF (PDB ID: 6UAN, A) and the inactive state (DFGout-BBAminus) of BRAF (PDB ID: 8C7X, B). The active site is focused in the red box on the right of each panel. The activation loop and DFG motif changes conformation depending on the state.