Fig. 3

Monitoring of tumor growth and metastasis in the spontaneous metastatic xenograft model. (a) Tumor growth in the control and sorafenib-treated groups. Data are presented as the mean ± SD (n = 4/group). (b) Comparison of luminescence between the control and sorafenib-treated groups. Dorsal images show the growth of primary tumor with time. Ventral images show metastatic lesions. Quantification of luminescence intensity. Data are presented as the mean ± SD (n = 4/group). *, p < 0.05 (two-way analysis of variance with Sidak’s post hoc test). (c) Isolated tumor tissues.