Fig. 7 | Scientific Reports

Fig. 7

From: Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes

Fig. 7

Scheme for formation of stable PHD2.Fe(III).2OG.(+/– HIFα) complexes. Note that the stoichiometries (and in some cases products) of the outlined mechanisms are uncertain. L-Asc hinders formation of the PHD2.Fe(III).2OG.(+/– HIFα) complexes and can restore them to the catalytically active PHD2.Fe(II).2OG complexes. SIN: succinate, L-Asc: L-ascorbate, DHA: dehydroascorbic acid.

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