Table 1 Overview of the data sources of phenotype used in the MR Study.

From: No genetic causal relationship between lung function and osteoporosis ― evidence from a mendelian randomization study

Phenotype

Sample Size (or Cases/Controls)

Number of

SNPsara>

Consortium/ Study PMID

Ancestry

GWAS ID

Year

FVC

321,047

19,676,344

30,804,560

European

ebi-a-GCST007429

2019

PEF

24,218

14,791,652

30,804,560

European

ebi-a-GCST007430

2019

FEV1/FVC

321,047

19,671,887

30,804,560

European

ebi-a-GCST007431

2019

FEV1

321,047

19,674,931

30,804,560

European

ebi-a-GCST007432

2019

Osteoporosis

3,203/209,575

16,380,452

FinnGen

European

finn-b-M13_OSTEOPOROSIS

2021

  1. Abbreviation: OP = osteoporosis, BMD = bone mineral density, FEV1 = forced expiratory volume in 1 s. FVC = forced vital capacity, PEF = peak expiratory flow; MR, Mendelian randomization; SNPs, Single nucleotide polymorphisms; MR = Mendelian randomization; GWAS = genome-wide association studies.