Fig. 1
From: Cognitive engagement may slow clinical progression and brain atrophy in Huntington’s disease
Higher Cognitive Reserve Questionnaire scores predict lower overall severity and rate of progression across time and symptom domains. Plots depict the prediction of the different models over time grouped by the different levels (quartiles and deciles) of lifelong cognitive engagement. Plot (A) represents cognitive decline (Model 1.1), plot (B) motor symptoms (Model 2.1), and plot (C) psychiatric disturbances (Model 3.1). Image generated with sjPlot package in R v.4.4.0. D1 = first decile; Q1 = first quartile; Q2 = median; Q3 = third quartile; D9 = ninth decile; PBA-s = short-Problem-Behavior Assessment; UHDRS-cogscore = Unified Huntington’s Disease Rating Scale total cognitive score; UHDRS-motor = Unified Huntington’s Disease Rating Scale total motor score.
