Table 3 Individual psychiatric items as independently predicted by CRQ score in combined HD group.

From: Cognitive engagement may slow clinical progression and brain atrophy in Huntington’s disease

	β Estimate	SE	95% CI	Z value	P value
Model 3a.0 – Mood null AIC = 1159.6; W = 0.360
CAP	-0.381	0.213	[-0.80, 0.04]	-1.79	0.074^†
Time^a	-0.177	0.182	[-0.53, 0.18]	-0.97	0.331
Sex	-0.065	0.217	[-0.49, 0.36]	-0.30	0.766
Model 3a.1 – Mood CRQ AIC = 1158.5; W = 0.640
CAP	-0.436	0.221	[-0.87, -0.004]	-1.98	0.048*
Time^a	-0.164	0.173	[-0.50, 0.18]	-0.95	0.343
Sex	-0.034	0.217	[-0.46, 0.39]	-0.16	0.875
CRQ	-0.394	0.234	[-0.85, 0.07]	-1.68	0.093^†
CRQ ✕ Time^a	-0.351	0.167	[-0.68, -0.02]	-2.10	0.036*
Model 3b.0 – Apathy null AIC = 955.5; W = 0.023
CAP	0.306	0.217	[-0.12, 0.73]	1.41	0.159
Time^a	-0.113	0.159	[-0.42, 0.20]	-0.71	0.478
Sex	-0.598	0.291	[-1.17, -0.03]	-2.06	0.040*
Model 3b.1 – Apathy CRQ AIC = 948.1; W = 0.977
CAP	0.159	0.210	[-0.25, 0.57]	0.76	0.447
Time^a	-0.134	0.160	[-0.45, 0.18]	-0.84	0.404
Sex	-0.453	0.259	[-0.96, 0.05]	-1.75	0.080^†
CRQ	-0.659	0.229	[-1.11, -0.21]	-2.87	0.004**
CRQ ✕ Time^a	-0.300	0.157	[-0.61, 0.01]	-1.91	0.057^†
Model 3c.0 – Dysexecutive behaviors null AIC = 987.6; W = 0.012
CAP	0.317	0.160	[0.004, 0.63]	1.99	0.047*
Time^a	0.101	0.115	[-0.12, 0.33]	0.88	0.380
Sex	-0.484	0.155	[-0.79, -0.18]	-3.13	0.002**
Model 3c.1 – Dysexecutive behaviors CRQ AIC = 978.8; W = 0.988
CAP	0.161	0.160	[-0.14, 0.47]	1.03	0.302
Time^a	0.136	0.113	[-0.09, 0.36]	1.21	0.228
Sex	-0.366	0.147	[-0.66, -0.08]	-2.48	0.013*
CRQ	-0.601	0.164	[-0.92, -0.28]	-3.67	<0.001***
CRQ ✕ Time^a	0.192	0.115	[-0.03, 0.42]	1.67	0.096^†
Model 3d.0 – Irritability/aggression null AIC = 808.8; W = 0.326
CAP	0.111	0.282	[-0.44, 0.66]	0.39	0.694
Time^a	0.029	0.194	[-0.35, 0.41]	0.15	0.883
Sex	-0.416	0.297	[-1.00, 0.17]	-1.40	0.162
Model 3d.1 – Irritability/aggression CRQ AIC = 807.4; W = 0.674
CAP	-0.042	0.280	[-0.59, 0.51]	-0.15	0.881
Time^a	0.010	0.196	[-0.37, 0.39]	0.05	0.961
Sex	-0.261	0.291	[-0.83, 0.31]	-0.90	0.369
CRQ	-0.642	0.285	[-1.20, -0.08]	-2.25	0.024*
CRQ ✕ Time^a	-0.145	0.189	[-0.52, 0.23]	-0.77	0.443

All regression estimates are standardized.
*P-values significant at P<0.05. **P-values significant at P<0.01. ***P-values significant at P<0.001.
^†P-values approaching significance.
^aTime in days (accumulative, time at first assessment is zero).
AIC=Akaike’s information criteria; CAP=standardized CAG-age product⁸⁷; CRQ=Cognitive Reserve Questionnaire⁹¹; HD=Huntington’s disease; W=Akaike’s information criteria weight^97,98.

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Table 3 Individual psychiatric items as independently predicted by CRQ score in combined HD group.

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