Table 1 Clinical characteristics of the study population according to the presence or absence of SLD.
Total | No SLD | SLD | P-value | |
|---|---|---|---|---|
N (%) | 1446 | 1155(79.9) | 291(20.1) | |
Age (years) | 15.0 ± 2.0 | 14.9 ± 2.0 | 15.3 ± 1.9 | 0.001 |
Female sex (%) | 680 (47.0) | 552 (47.8) | 128 (44.0) | 0.245 |
BMI(kg/m2) | 24.6 ± 6.7 | 22.7 ± 4.8 | 32.1 ± 7.9 | < 0.001 |
BMI categories (%) | < 0.001 | |||
< 5th percentile (underweight) | 45(3.1) | 44 (3.8) | 1 (0.3) | |
5th – 85th percentile (normal weight) | 780 (54.4) | 740 (64.7) | 40 (13.8) | |
85th – 95th percentile (overweight) | 248 (17.3) | 209 (18.3) | 39 (13.4) | |
≥ 95th percentile (obese) | 360 (25.1) | 150 (13.1) | 210 (72.4) | |
Waist circumference (cm) | 82.7 ± 16.0 | 77.9 ± 11.7 | 101.5 ± 16.8 | < 0.001 |
Race-ethnicity (%) | 0.065 | |||
Non-Hispanic White | 465 (32.2) | 377 (32.6) | 88 (30.2) | |
Non-Hispanic Black | 356 (24.6) | 294 (25.5) | 62 (21.3) | |
Hispanic | 128 (8.9) | 106 (9.2) | 22 (7.6) | |
Other | 497 (34.4) | 378 (32.7) | 119 (40.9) | |
Alcohol consumption (%) | 0.853 | |||
Light alcohol use | 1384 (95.7) | 1107 (95.8) | 277 (95.2) | |
Moderate alcohol use | 38 (2.6) | 29 (2.5) | 9 (3.1) | |
Excessive alcohol use | 24 (1.7) | 19 (1.6) | 5 (1.7) | |
Laboratory Features | ||||
AST (IU/L) | 19.8 ± 9.2 | 19.4 ± 9.2 | 21.6 ± 9.4 | < 0.001 |
ALT (IU/L) | 16.2 ± 11.5 | 14.2 ± 7.3 | 24.3 ± 19.0 | < 0.001 |
Elevated ALT (%) | 52 (4.2) | 18 (1.8) | 34 (13.5) | < 0.001 |
ALT ≥ 80 IU/L | 4 (0.3) | 0 (0.0) | 4 (1.6) | 0.002 |
GGT(IU/L) | 15.1 ± 8.8 | 13.8 ± 6.8 | 20.4 ± 12.7 | < 0.001 |
Platelet count (×10^9/L) | 269.1 ± 57.7 | 264.7 ± 56.7 | 286.6 ± 58.8 | < 0.001 |
Albumin (g/dl) | 4.3 ± 0.3 | 4.3 ± 0.3 | 4.2 ± 0.3 | < 0.001 |
Total cholesterol (mg/dl) | 153.3 ± 29.5 | 151.5 ± 28.9 | 160.5 ± 30.5 | < 0.001 |
LDL-C(mg/dl) | 87.3 ± 25.4 | 85.4 ± 24.9 | 94.2 ± 26.1 | < 0.001 |
CMRF Groups (%) | ||||
Group 1: Overweight or obesity | 608 (42.4) | 359 (31.4) | 249 (85.9) | < 0.001 |
Group 2: Prediabetes or diabetes | 292 (20.2) | 207 (17.9) | 85 (29.2) | < 0.001 |
Group 3: Elevated BP | 96 (6.6) | 67 (5.8) | 29 (10.0) | < 0.001 |
Group 4: Hypertriglyceridemia | 23 (1.6) | 8 (0.7) | 15 (5.2) | < 0.001 |
Group 5: Low HDL-C | 204 (14.1) | 126 (10.9) | 78 (26.8) | < 0.001 |
MASLD (%) | 260 (17.9) | 0 (0.0%) | 260 (89.3) | < 0.001 |
MetALD (%) | 9 (0.6%) | 0 (0.0) | 9 (3.1) | < 0.001 |
ALD (%) | 5 (0.3%) | 0 (0.0) | 5 (1.7) | < 0.001 |
CSF (%) | 58 (4.0) | 30 (2.6) | 28 (9.6) | < 0.001 |
