Table 2 Clinical characteristics of adolescents with SLD based on whether they met the MASLD criteria.
MASLD – (N = 31 ) | MASLD + (N = 260) | P – value | |
|---|---|---|---|
Age (years) | 15.0 ± 1.9 | 15.4 ± 1.8 | 0.263 |
Female sex (%) | 14 (45.2%) | 114 (43.8%) | 0.889 |
BMI(kg/m2) | 21.2 ± 2.5 | 33.4 ± 7.3 | < 0.001 |
BMI categories (%) | < 0.001 | ||
< 5th percentile (underweight) | 1 (3.3) | 0 (0.0) | |
5th – 85th percentile (normal weight) | 29 (96.7) | 11 (4.2) | |
85th – 95th percentile (overweight) | 0 (0.0) | 39 (15.0) | |
≥ 95th percentile (obese) | 0 (0.0) | 210 (80.8) | |
Waist circumference (cm) | 75.4 ± 7.7 | 104.5 ± 14.8 | < 0.001 |
Race-ethnicity (%) | 0.749 | ||
Non-Hispanic White | 9 (29.0) | 79 (30.4) | |
Non-Hispanic Black | 8 (25.8) | 54 (20.8) | |
Hispanic | 1 (3.2) | 21 (8.1) | |
Other | 13 (41.9) | 106 (40.8) | |
Alcohol consumption (%) | 0.441 | ||
Light alcohol intake | 30 (96.8%) | 247 (95.0%) | |
Moderate alcohol intake | 0 (0.0%) | 9 (3.5%) | |
Excessive alcohol intake | 1 (3.2%) | 4 (1.5%) | |
AST (IU/L) | 20.3 ± 8.1 | 21.8 ± 9.5 | 0.244 |
ALT (IU/L) | 15.8 ± 7.5 | 25.1 ± 9.5 | 0.002 |
Elevated ALT (%) | 1 (3.2%) | 33 (12.7%) | 0.013 |
ALT ≥ 80 IU/L | 0 (0.0%) | 4 (1.5%) | 0.038 |
GGT(IU/L) | 12.3 ± 3.6 | 21.1 ± 13.0 | < 0.001 |
Platelet count (× 10^6/L) | 279.6 ± 57.6 | 287.3 ± 59.0 | 0.304 |
Albumin (g/dl) | 4.3 ± 0.2 | 4.1 ± 0.3 | 0.002 |
Total cholesterol (mg/dl) | 157.4 ± 24.1 | 160.8 ± 31.1 | 0.779 |
LDL-C (mg/dl) | 85.6 ± 24.9 | 94.1 ± 26.1 | 0.002 |
CMRF Groups (%) | |||
Group 1: Overweight or obesity | 0 (0.0%) | 249 (95.8%) | < 0.001 |
Group 2: Prediabetes or diabetes | 0 (0.0%) | 85 (32.7%) | < 0.001 |
Group 3: Elevated BP | 0 (0.0%) | 29 (11.2%) | 0.050 |
Group 4: Hypertriglyceridemia | 0 (0.0%) | 15 (5.8%) | 0.170 |
Group 5: Low HDL-C | 0 (0.0%) | 78 (30.0%) | < 0.001 |
MetALD (%) | 0 (0.0%) | 9 (3.5%) | 0.604 |
ALD (%) | 1 (3.2%) | 4 (1.5%) | 0.433 |
CSF (%) | 3 (9.7) | 25 (9.6) | 0.991 |
