Fig. 2 | Scientific Reports

Fig. 2

From: Increased expression of the proapoptotic presenilin associated protein is involved in neuronal tangle formation in human brain

Fig. 2

Presenilin-associated protein (PSAP) IR in the temporal lobe regions in a probable Alzheimer’s disease (pAD) human brain. (A) Low magnification view, with the framed areas enlarged sequentially as indicated. PSAP IR is apparently enhanced in a subpopulation of pyramidal neurons in the temporal neocortex (B-B2, C-C2) and subicular and CA subregions (D, D1), and mossy cells in the dentate gyrus (D, D2). These darkly labeled neurons show a tangle-like morphological appearance. Heavily labeled neuritic processes (as pointed by arrows) are also present in the cortical and hippocampal regions. CA1-CA3: Ammon’s horn subregions; DG: dentate gyrus; FG: fusiform gyrus; GCL: granule cell layer: Hi: hilus; ITG: inferior temporal gyrus; I-VI: cortical layers I to VI; ML: molecular layer; MTG: middle temporal gyrus; PHG: parahippocampal gyrus; Pro-S: prosubiculum; Pre-S: presubiculum; Sub: subiculum; s.o.: stratum oriens; s.p.: stratum pyramidale; s.r.: stratum radiatum, WM: white matter. Scale bars are as indicated.

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