Fig. 8 | Scientific Reports

Fig. 8

From: Increased expression of the proapoptotic presenilin associated protein is involved in neuronal tangle formation in human brain

Fig. 8

Comparative assessment of presenilin-associated protein (PSAP), phosphorylated tau (pTau) and β-amyloid (Aβ) IR in 3xTg-AD and C57BL/6J mouse forebrain. Light PSAP immunolabeling is present in the cerebral cortex and hippocampal formation, localized to the somata and dendrites of pyramidal neurons, which is similar between the 3xTg-AD (A-A3) and C57BL/6J (D-D2) brain sections. pTau IR is distinct in cortical and hippocampal pyramidal neurons in the transgenics (B-B3), which is absent in the C57BL/6J mouse brain section (E-E2). Aβ deposition is seen only in the transgenics, most evident in the subicular and CA1 areas (C-C3; F-F1). CA1 and CA2: Ammon’s horn subregions; DG: dentate gyrus; III-VI: cortical layers; WM: white matter. Scale bars are indicated.

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