Fig. 8 | Scientific Reports

Fig. 8

From: The overexpression of human amylin in pancreatic β cells facilitate the appearance of amylin aggregates in the kidney contributing to diabetic nephropathy

Fig. 8

Scheme of the main results. This work shows for the first time the pathological role of hIAPP, which has been found to be deposited in the kidneys of ND patients. TghIAPP 8 M mice treated with HFD exhibit hIAPP aggregates and an increased in mTORC1 signaling pathway, inflammation, and altered mitochondrial dynamics.

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