Fig. 5

Classification of unclassified cases with gene expression profiles in fibrosis or uninvolved regions. (a) Flowchart depicting a strategy to group unclassified cases as one of IPF, CHP, or NSIP. (b) Heatmap of top (sorted by F statistic) differentially expressed genes between fibrotic regions across conditions that were identified in Fig. 3b. Expression is shown as row-scaled Z scores. Columns are clustered based on the complete agglomeration method. Patient ID and condition are indicated by color bars above the heatmap. (c) PCA plot showing central regions in bona fide normal (triangle), and uninvolved regions in IPF (circle), CHP (square), and unclassified cases (diamond). Clusters of IPF and CHP are enclosed in pink or blue ellipses, respectively. Unc.: unclassified.