Table 2 Frequencies of QRDRs mutation amongst E.coli isolate highlighting co-occurrence of amino acid substitution within gyrase A (gyrA) and topoisomerase IV (parC).

From: Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81

QRDRs mutations (N)

Isolates N (%)

Amino acid substitution

N (%)

GyrA

ParC

1

11 (16,41%)

7(10,44%)

1(1,49%)

1(1,49%)

2(1,49%)

S83L

S83T

S83Y

D87N

-

-

-

-

2

11 (16,41%)

5(7,46%)

4(5,97%)

1(1,49%)

1(1,49%)

S83L + D87N

S83L

S83W

D87N

-

S80I

S80I

S80I

3

36 (53,73%)

35(52,23%)

1(1,49%)

S83L + D87N

S83L + D87N

S80I

E84K

4

9 (13,43%)

7(10,44%)

1(1,49%)

1(1,49%)

S83L + D87N

S83L + D87N

S83L + D87N

S80I + E84V

S80L + E84V

S80I + E84G

  1. S: Serine; L: Leucine; I: Isoleucine; D: Aspartate; N: Asparagine; T: Threonine; Y: Tyrosine; W: Tryptophan; E: Glutamic acid; G: Glysine; V: Valine; K: Lysine.
Back to article page