Table 2 Correlation analysis of ACER1 expression and gene markers of immune cells in HNSC via TIMER2.0.
Immune Cell | Gene markers | HNSC | |||
|---|---|---|---|---|---|
None | Purity | ||||
Cor | P | Cor | P | ||
T cell (general) | CD3D | -0.058 | 0.183 | -0.13 | ** |
CD3E | -0.011 | 0.807 | -0.082 | 0.0681 | |
CD2 | -0.044 | 0.312 | -0.111 | * | |
CD4 + T cell | CD4 | -0.052 | 0.234 | -0.12 | ** |
CD8 + T cell | CD8A | -0.006 | 0.897 | -0.071 | 0.116 |
CD8B | -0.037 | 0.398 | -0.095 | * | |
Th1 | T -bet (TBX21) | -0.016 | 0.707 | -0.07 | 0.123 |
STAT4 | -0.134 | ** | -0.197 | *** | |
STAT1 | 0.031 | 0.475 | -0.004 | 0.931 | |
IFN-γ (IFNG) | -0.031 | 0.295 | -0.091 | * | |
TNF-α (TNF) | -0.071 | 0.106 | -0.094 | * | |
Th2 | GATA3 | 0.04 | 0.367 | -0.014 | 0.754 |
STAT6 | -0.075 | 0.088 | -0.06 | 0.186 | |
STAT5A | -0.169 | *** | -0.198 | *** | |
IL13 | -0.015 | 0.737 | -0.066 | 0.145 | |
Tfh | BCL6 | 0.057 | 0.19 | 0.101 | * |
IL21 | 0.002 | 0.97 | -0.033 | 0.461 | |
Th17 | STAT3 | 0.114 | ** | 0.116 | ** |
IL17A | 0.054 | 0.217 | 0.023 | 0.616 | |
Treg | FOXP3 | 0.019 | 0.665 | -0.037 | 0.414 |
CCR8 | 0.079 | 0.0707 | 0.034 | 0.445 | |
STAT5B | -0.08 | 0.0678 | -0.097 | * | |
TGFβ (TGFB1) | -0.036 | 0.413 | -0.054 | 0.233 | |
T cell exhaustion | PD-1 (PDCD1) | -0.069 | 0.115 | -0.113 | ** |
PDL1(PDCD1LG2) | -0.067 | 0.125 | -0.136 | ** | |
CTLA4 | -0.079 | 0.0728 | -0.149 | *** | |
LAG3 | -0.117 | ** | -0.177 | *** | |
TIM-3 (HAVCR2) | -0.127 | ** | -0.195 | *** | |
GZMB | -0.096 | * | -0.158 | *** | |
B cell | CD19 | 0.031 | 0.475 | -0.025 | 0.579 |
CD79A | 0.063 | 0.151 | 0.014 | 0.750 | |
Monocyte | CD86 | -0.142 | ** | -0.291 | *** |
CD115 (CSF1R) | -0.07 | 0.112 | -0.145 | ** | |
Neutrophils | CD66b (CEACAM8) | 0.033 | 0.451 | 0.028 | 0.533 |
CD11b (ITGAM) | -0.005 | 0.904 | -0.038 | 0.398 | |
CCR7 | 0.045 | 0.309 | -0.017 | 0.714 | |
TAM | CCL2 | -0.024 | 0.581 | -0.09 | * |
CD68 | -0.05 | 0.252 | -0.088 | 0.0503 | |
IL10 | 0.012 | 0.792 | -0.061 | 0.178 | |
M1 Macrophage | INOS (NOS2) | -0.079 | 0.0696 | -0.069 | 0.125 |
IRF5 | 0.028 | 0.519 | 0.034 | 0.447 | |
COX2(PTGS2) | -0.03 | 0.494 | -0.023 | 0.608 | |
M2 Macrophage | CD163 | -0.065 | 0.136 | -0.132 | ** |
VSIG4 | -0.11 | * | -0.174 | *** | |
MS4A4A | -0.1 | * | -0.174 | *** | |
Natural killer cell | KIR2DL1 | -0.036 | 0.41 | -0.068 | 0.132 |
KIR2DL3 | -0.099 | * | -0.124 | ** | |
KIR2DL4 | -0.08 | 0.0674 | -0.118 | ** | |
KIR3DL1 | -0.044 | 0.314 | -0.073 | 0.107 | |
KIR3DL2 | -0.047 | 0.285 | -0.083 | 0.0668 | |
KIR3DL3 | -0.13 | ** | -0.158 | *** | |
KIR2DS4 | -0.037 | 0.402 | -0.072 | 0.111 | |
Dendritic cell | HLA-DPB1 | -0.071 | 0.104 | -0.146 | ** |
HLA-DQB1 | -0.104 | * | -0.156 | *** | |
HLA-DRA | -0.028 | 0.524 | -0.097 | * | |
HLA-DPA1 | -0.034 | 0.436 | -0.1 | * | |
BDCA-1(CD1C) | 0.077 | 0.0783 | 0.031 | 0.488 | |
BDCA-4(NRP1) | -0.104 | * | -0.151 | *** | |
CD11c (ITGAX) | 0.055 | 0.213 | -0.123 | ** | |
