Fig. 3
EVsHSHS reduce cerebral infarct volume and decrease mNSS in cerebral ischemic rats on day 7 after pMCAO. (A) Changes in body weight of pMCAO rats. Data are presented as mean ± SEM, n = 7. (B) mNSS results in pMCAO rats (normal score, 0; maximal deficit score, 18). 13–18 indicates severe injury; 7–12, moderate injury; 1–6, mild injury. Data are presented as Min to Max, n = 7. (C,D) MRI detection of infarct volume. Infarcted areas are indicated by high density in the cortex and striatum, and outlined in each slice with dotted lines. EVsNC-L, 50 µg/100 g weight of EVsNC; EVsNC-H, 100 µg/100 g weight of EVsNC; EVsHSHS-L, 50 µg/100 g weight of EVsHSHS; EVsHSHS-H, 100 µg/100 g weight of EVsHSHS. Data are presented as mean ± SD, n = 3. *P < 0.05, ***P < 0.001, vs. the Model group. ∆∆P < 0.01, ∆∆∆P < 0.001, vs. the EVsHSHS-H group.
