Fig. 4
EVsHSHS enhance cortical angiogenesis and improve perfusion in cerebral ischemic rats on day 7 after pMCAO. (A) Cerebral blood flow across groups. (B) rCBF in different brain regions. (C,D) Vascular density in the cortical tissue. Scale bar = 100 μm. (E) HE staining of rat brain sections. Scale bar = 50 μm (top), scale bar = 1 mm (bottom). EVsNC-L, 50 µg/100 g weight of EVsNC; EVsNC-H, 100 µg/100 g weight of EVsNC; EVsHSHS-L, 50 µg/100 g weight of EVsHSHS; EVsHSHS-H, 100 µg/100 g weight of EVsHSHS. Data are presented as mean ± SD, n = 3. ###P < 0.001, vs. the Sham group. *P < 0.05, **P < 0.01, ***P < 0.001, vs. the Model group. ∆P < 0.05, vs. the EVsHSHS-H group.
