Fig. 5 | Scientific Reports

Fig. 5

From: Extracellular vesicles derived from endothelial progenitor cells modified by Houshiheisan promote angiogenesis and attenuate cerebral ischemic injury via miR-126/PIK3R2

Fig. 5

EVsHSHS regulate miR-126 expression and key molecules of the PIK3R2/PI3K/AKT pathway in cerebral ischemic rats on day 7 after pMCAO. (A) miR-126 expression levels in the cortex. (B–E) Protein levels of PIK3R2, PI3K, and p-AKT in the cortex. Original blots are shown in Supplementary Figures. EVsNC-L, 50 µg/100 g weight of EVsNC; EVsNC-H, 100 µg/100 g weight of EVsNC; EVsHSHS-L, 50 µg/100 g weight of EVsHSHS; EVsHSHS-H, 100 µg/100 g weight of EVsHSHS. Data are presented as mean ± SD, n = 3. #P < 0.05, ###P < 0.001, vs. the Sham group. *P < 0.05, **P < 0.01, ***P < 0.001, vs. the Model group. ∆P < 0.05, ∆∆P < 0.01, vs. the EVsHSHS-H group.

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